![]() ![]() Their cytotoxicity was estimated on Vero cells, and their 50% inhibitory concentrations (IC 50) were further calculated. A preliminary in vitro screening performed over 72 h by an enzyme-linked immunosorbent assay (ELISA) revealed 15 interesting compounds that were effective against T. In this study, the 400 compounds of the open-access Pathogen Box, provided by the Medicines for Malaria Venture (MMV) foundation, were screened for their anti- Toxoplasma gondii activity. Thus, it is important to find new compounds able to inhibit parasite invasion or proliferation. The drugs currently used against toxoplasmosis are few in number and show several limitations, such as drug intolerance, poor bioavailability, or drug resistance mechanism developed by the parasite. ![]() Toxoplasma gondii is a cosmopolitan protozoan parasite which affects approximately 30% of the population worldwide. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
December 2022
Categories |